Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 114615-82-6, Name is Tetrapropylammonium perruthenate, Application In Synthesis of Tetrapropylammonium perruthenate.
Differential effect of wortmannolone derivatives on MDA-MB-231 breast cancer cells
Background/Aim: The survival rate of women diagnosed with triple-negative breast-cancer (TNBC) remains low. Hence, this study aimed at the chemical and biological optimization of furanosteroid derivatives for the treatment of this type of malignancy using TNBC cells. Materials and Methods: Semi-synthetic analogs of wortmannolone (1-6) that negatively affected the aberrant pathways in tumor cells were evaluated in hormoneindependent breast cancer cells using western blot and cellcycle analysis. Results: Wortmannolone derivatization generated NF-?B inhibitors as new lead structures for further development. Compound (3) was found to be the most significantly active lead. Conclusion: Structure-activity analysis in the present study showed that acetylation of the hydroxyl groups and substitution on C3 and C17 of wortmannolone enhanced biological activity. Alphasubstitution of the acetyl group in C3 on ring A (compound 3) resulted in ROS inducing effect; however, presence of an acetyl group in beta-position of C3 displayed the highest NF-?B p65 inhibitory activity (0.60 muM).
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of Tetrapropylammonium perruthenate. In my other articles, you can also check out more blogs about 114615-82-6
Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI