A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 15746-57-3, Name is Cis-Dichlorobis(2,2′-bipyridine)ruthenium(II), molecular formula is C20H16Cl2N4Ru. In a Article£¬once mentioned of 15746-57-3, Recommanded Product: 15746-57-3
Nanosecond photoreduction of cytochrome P450cam by channel-specific Ru-diimine electron tunneling wires
We report the synthesis and characterization of Ru-diimine complexes designed to bind to cytochrome P450cam (CYP101). The sensitizer core has the structure [Ru(L2)L’]2+, where L’ is a perfluorinated biphenyl bridge (F8bp) connecting 4,4?-dimethylbipyridine to an enzyme substrate (adamantane, F8bp-Ad), a heme ligand (imidazole, F8bp-lm), or F (F9bp). The electron-transfer (ET) driving force (-deltaG) is varied by replacing the ancillary 2,2? -bipyridine ligands with 4,4?,5,5?-tetramethylbipyridine (tmRu). The four complexes all bind P450cam tightly: Ru-F8bp-Ad (1, K d = 0.077 muM); Ru-F8bp-lm (2, Kd = 3.7 muM); tmRu-F9bp (3, Kd = 2.1 muM); and tmRu-F 8bp-lm (4, Kd = 0.48 muM). Binding is predominantly driven by hydrophobic interactions between the Ru-diimine wires and the substrate access channel. With Ru-F8bp wires, redox reactions can be triggered on the nanosecond time scale. Ru-wire 2, which ligates the heme iron, shows a small amount of transient heme photoreduction (ca. 30%), whereas the transient photoreduction yield for 4 is 76%. Forward ET with 4 occurs in roughly 40 ns (kf = 2.8 ¡Á 107 s-1), and back ET (FeII ? RuIII, kb ? 1.7 ¡Á 108 s-1) is near the coupling-limited rate (k max). Direct photoreduction was not observed for 1 or 3. The large variation in ET rates among the Ru-diimine:P450 conjugates strongly supports a through-bond model of Ru-heme electronic coupling.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Recommanded Product: 15746-57-3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 15746-57-3, in my other articles.
Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI