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ANTAGONISTS OF GONADOTROPIN RELEASING HORMOME

There are disclosed compounds of formula (I) STR1 and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.

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Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

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The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.114615-82-6, Name is Tetrapropylammonium perruthenate, molecular formula is C12H28NO4Ru. In a Patent£¬once mentioned of 114615-82-6, Quality Control of: Tetrapropylammonium perruthenate

Compounds having activity as inhibitors of cytochrome P450RAI

Compounds having Formula 1 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.

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Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

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The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 114615-82-6 is helpful to your research., category: ruthenium-catalysts

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.114615-82-6, Name is Tetrapropylammonium perruthenate, molecular formula is C12H28NO4Ru. In a Article£¬once mentioned of 114615-82-6, category: ruthenium-catalysts

Concentrated solar radiation aided energy efficient protocol for oxidation of alcohol using biodegradable task specific ionic liquid-choline peroxydisulfate

An eco-friendly and energy efficient protocol for selective oxidation of alcohols to aldehydes/ketones has been developed by using Choline Peroxydisulfate under concentrated solar radiation (CSR). Choline and peroxydisulfate based biodegradable oxidizing task specific ionic liquid (TSIL) ChPS was synthesized, characterized, and evaluated. The oxidizing property shows excellent performance as an effective oxidant. Comparative energy calculations between conventional and CSR method show, CSR method is superior alternative pathway with high energy conservation method (?90%). Incorporation of biodegradable ionic liquid and renewable energy source, makes the present protocol environmentally benign and energy efficient.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 114615-82-6 is helpful to your research., category: ruthenium-catalysts

Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

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Farnesyl pyrophosphate analogs

The present invention is directed to farnesyl pyrophosphate analogs which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention, and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

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Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

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PHENOXY DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS

The present invention relates to phenoxy derivatives, processes for preparing them, pharmaceutical compositions containing them, and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.

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Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

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The indole-based subincanadine alkaloids and their biogenetic congeners

The tryptamine-derived polycyclic bridged bioactive indole alkaloids subincanadines A?G were isolated in 2002 by Ohsaki and coworkers from the bark of the Brazilian medicinal plant Aspidosperma subincanum. Kobayashi proposed that subincanadines D?F could be biosynthetically resulting from stemmadenine via two different pathways and, furthermore, that the subincanadines A?C could be biogenetically resulting from subincanadines D and E. Kam and coworkers, in their focused efforts, isolated five indole alkaloids from Malaysian Kopsia arborea species, namely valparicine, apparicine, arboridinine, arborisidine, and arbornamine in combination with subincanadine E. On the basis of structural features, it has been proposed and proved in some examples that subincanadine E is a biogenetic precursor of these five different bioactive indole alkaloids bearing complex structural architectures. All important information on isolation, characterization, bioactivity, probable biogenetic pathways, and more specifically racemic and enantioselective total synthesis of subincanadine alkaloids and their biogenetic congeners are summarized in the present chapter. Special importance is given to the total synthesis and the synthetic strategies intended therein, comprising a set of main reactions.

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Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

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Parasiticidal pyrazoles

Compounds of formula (I): STR1 or pharmaceutically, veterinarily or agriculturally acceptable salts thereof, or pharmaceutically, veterinarily or agriculturally acceptable solvates of either entity, wherein R1 is 2,4,6-trisubstituted phenyl or 3,5-disubstituted pyridin-2-yl; R3 is hydrogen; C2 to C5 alkyl substituted with one or more halo and with hydroxy; C2 to C5 alkanoyl substituted with one or more halo; C2 to C6 alkenyl optionally substituted with one or more halo; halo; amino or CONH2 ; R5 is hydrogen, amino or halo; R2 and R4 are each independently selected from hydrogen, fluoro, chloro and bromo; R6 and R8 are hydrogen; and R7 is hydrogen or C1 to C4 alkyl optionally substituted with one or more halo; are parasiticidal agents.

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Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 114615-82-6, Name is Tetrapropylammonium perruthenate, molecular formula is C12H28NO4Ru. In a Article£¬once mentioned of 114615-82-6, Quality Control of: Tetrapropylammonium perruthenate

Surface-active ionic liquids in catalysis: Impact of structure and concentration on the aerobic oxidation of octanol in water

We present design and synthesis of surface-active ionic liquids for the application in micellar catalysis. A series of 1-methyl-3-dodecylimidazolium based ionic liquids with variable core structures including dicationic and zwitterionic ones was synthesized and characterized. These surface-active ionic liquids where applied in the aerobic oxidation of aliphatic alcohols to carbonyl compounds. A strong dependence on the ionic liquid concentration and structure was identified, which is in accordance with the concepts of micellar catalysis. Optimum conditions for the oxidation of 1-octanol could be identified, and the use of surface-active ionic liquids strongly improved the reaction performance compared to pure water. Under optimized conditions, it was possible to isolate up to 75% of octanoic acid using only small amounts of surface-active ionic liquid in a 0.05?mM solution in water without further ligands.

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Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

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Nanoporous solids as receptacles and catalysts for unusual conversions of organic compounds

Solid-state chemical principles, allied to a degree of chemical intuition, enables one to design open-structure solids on to the inner surfaces of which isolated catalytically active sites of different kinds may be placed. With such solids, which act simultaneously both as permeable catalysts and reaction vessels, a number of highly desirable chemical conversions – many of paramount importance in the context of “green” chemistry and clean technology – may be smoothly effected under environmentally benign conditions. Typical examples, illustrated here, include the selective oxidation of toluene to benzaldehyde, current methods of producing alcohols, aldehydes and acids, and the synthesis of epsilon-caprolactam in a by-product-free manner. Such open-structure solids, which house single-site active centres, are also readily amenable to detailed and precise structural elucidation.

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Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

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Solvent-free aerobic alcohol oxidation using Cu/Nb2O5: Green and highly selective photocatalytic system

Photooxidation of alcohols without organic solvents in the presence of O2 took place at the atmospheric pressure and room temperature over Nb2O5 and Cu/Nb2O5, avoiding the cost, toxicity, and purification problems associated with transition-metal systems. Loading of a small amount of copper on Nb2O5 significantly enhanced activity without lowering selectivity. On the other hand, loading of Pt, Ni, Rh, Ru, and Ag showed no promotion effect. The selectivities of the photooxidation of aliphatic, aromatic and heteroatom-containing alcohols over Cu/Nb2O5 were in the range of 80-99%. Cu/Nb2O5 was easily separated from the reaction mixture and was reusable without reducing the catalytic performance.

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Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI