Category: 246047-72-3

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.246047-72-3,(1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium,as a common compound, the synthetic route is as follows.

General procedure: To a Schlenk flask charged with Grubbs? catalyst 2 (0.42 g,0.50 mmol) and CuCl (0.05 g, 0.50 mmol), compound 14 (or 15, 16)(0.6 mmol) in 10 mL dry dichloromethane was added at room temperature under N2. The resulting mixture was stirred for 40 min at 40 C. After being cooled to room temperature, the reaction mixturewas filtered and the clear filtrate was collected. The solvent from the filtrate was evaporated under vacuum to give a residue. The residue was purified by silica gel chromatography (CH2Cl2:ethyl acetate 2:1 or pentanes: ethyl acetate 3:2 or 1:1) to givethe desired product as a green crystalline solid.

246047-72-3, The synthetic route of 246047-72-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhang, Yiran; Shao, Mingbo; Zhang, Huizhu; Li, Yuqing; Liu, Dongyu; Cheng, Yu; Liu, Guiyan; Wang, Jianhui; Journal of Organometallic Chemistry; vol. 756; (2014); p. 1 – 9;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.246047-72-3,(1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium,as a common compound, the synthetic route is as follows.

246047-72-3, To a solution of 9 (59.7 mg, 0.098 mmol) in anhydrous CH2Cl2 (6.0 ml) was added 2ndgeneration Grubbs catalyst (75.3 mg, 0.088 mmol) and CuCl (I) (19.8 mg, 0.20 mmol)under nitrogen at 30 C and stirred for 3 h. The reaction mixture was concentrated invacuo, and the residue was purified by column chromatography on silica gel (hexane /CH2Cl2 = 1 / 1) to give 2j (43.2 mg, 41%).Green crystals; mp 153-157 C; 1H NMR (270 MHz, CDCl3) delta 2.38 (s, 6H), 2.45 (s,12H), 4.21 (s, 1H), 4.90-4.82 (m, 1H), 6.62 (d, J = 12.4 Hz, 1H), 7.07 (s, 5H), 16.22 (s,1H); 19F NMR (466 MHz, CDCl3) delta -80.6 (3F), -106.3 (1F), -108.5 (2F), -121.4 (2F),-121.5 (2F), -122.6 (4F), -125.9 (2F); 13C NMR (68 MHz, CDCl3) delta 19.4, 20.9, 51.4,77.5, 102.8, 103.2, 122.3, 129.4, 139.1, 141.8, 155.8, 155.9, 158.3, 162.1, 209.2, 291.7;IR (FT) 3905, 3857, 3747, 3642, 3569, 2971, 2918, 2363, 2342, 1837, 1723, 1691, 1612,1586, 1486, 1424, 1293, 1213, 1156, 1104, 1029, 915, 846 cm-1; HRMS (FAB) m/z[M+H]+ calcd for C39H37Cl2F18N2ORu 1064.1039; found 1064.1049.

246047-72-3 (1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium 11147261, aruthenium-catalysts compound, is more and more widely used in various fields.

Reference£º
Article; Kobayashi, Yuki; Suzumura, Naoki; Tsuchiya, Yuki; Goto, Machiko; Sugiyama, Yuya; Shioiri, Takayuki; Matsugi, Masato; Synthesis; vol. 49; 8; (2017); p. 1796 – 1807;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

(1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium, cas is 246047-72-3, it is a common heterocyclic compound, the ruthenium-catalysts compound, its synthesis route is as follows.,246047-72-3

General procedure: To a Schlenk flask charged with Grubbs? catalyst 2 (0.42 g,0.50 mmol) and CuCl (0.05 g, 0.50 mmol), compound 14 (or 15, 16)(0.6 mmol) in 10 mL dry dichloromethane was added at room temperature under N2. The resulting mixture was stirred for 40 min at 40 C. After being cooled to room temperature, the reaction mixturewas filtered and the clear filtrate was collected. The solvent from the filtrate was evaporated under vacuum to give a residue. The residue was purified by silica gel chromatography (CH2Cl2:ethyl acetate 2:1 or pentanes: ethyl acetate 3:2 or 1:1) to givethe desired product as a green crystalline solid.

As the rapid development of chemical substances, we look forward to future research findings about 246047-72-3

Reference£º
Article; Zhang, Yiran; Shao, Mingbo; Zhang, Huizhu; Li, Yuqing; Liu, Dongyu; Cheng, Yu; Liu, Guiyan; Wang, Jianhui; Journal of Organometallic Chemistry; vol. 756; (2014); p. 1 – 9;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.246047-72-3,(1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium,as a common compound, the synthetic route is as follows.

Under an argon atmosphere a carbene complex of formula 5.II, wherein L represents a NHC ligand of formula 6a.II (153 mg, 0.18 mmol),and anhydrous CuCl (18 mg, 0.18 mmol) were placed in a Schlenck tube. Then dry, deoxygenated CH2C12 (10 ml) was added followed by a solution of compound 2.1 (38 mg, 0.18 mmol) in CH2C12 (4 ml). The resulting suspension was stirred at 30C for 1 h, thereafter it was concentrated in vacuum, and purified by silica-gel column chromatography (cyclohexane / EtOAc 5:2). After removal of solvent and washing with small amount of dry n-pentane complex 1.II, wherein Mes has the meaning of a mesityl group, was obtained as green, microcrystalline solid (100 mg, 83% of yield). Rf = 0.30 (hexane/EtOAc8:2);XH-NMR (500 MHz, CD2Cl2): delta[ppm]= 16.42 (s, 1H), 8.46 (dd, 1H, J = 9.1, 2.5 Hz), 7.80 (d, 1H, J = 2.5 Hz), 7.10 (s, 4H), 6:94 (d, 1H, J = 9.1 Hz), 5.01 (sept, 1H, J = 6.1 Hz), 4.22 (s, 4H), 2.47 (2s, 18H), 1.30 (d, 6H, J = 6.1 Hz); 13C-NMR (125 MHz, CD2Cl2): delta;[ppm]= 289.1, 208.2,156.8, 150.3, 145.0, 143.5, 139.6,139.3,129.8, 124.5,117.2,113.3, 78.2, 52.0, 21.3, 21.2,19.4; IR (KBr): nu [cm-1] = 2924, 2850,1606,1521,1480,1262, 1093, 918,745; MS (ESI): m/z 636 [M-CI]+; HRMS(EI): m/z calculated for C31H37N3O3Ru: [M+.] 671.1255, found 671.1229; Elemental analysis, calculated: (%) for C31H37N3O3Ru (671.63): C 55.44, H 5.55, N 6.26; found: C 55.35; H 5.70, N 6.09., 246047-72-3

The synthetic route of 246047-72-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

246047-72-3, (1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium is a ruthenium-catalysts compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 5 – Synthesis of the complex 4 according to the invention The commercially available complex G (200 mg, 0.24 mmol) was placed in a flask, to which methylene chloride was added (6 ml). This was followed by adding the compound of the formula: (78 mg, 0.47 mmol) and tricyclohexylphosphine (132 mg, 0.47 mmol). The resulting solution was stirred at a temperature of 40C for 1 hour. The reaction mixture was introduced at the top of a chromatographic column packed with silica gel (eluent: ethyl acetate/cyclohexane, 0 to 10 vol.%). After evaporating the solvents, the complex 4 was obtained as a brown solid (104 mg, 50% yield). 4 H NMR (500 MHz, CD2CI2) delta ppm: 16.42 (s, 1H), 8.00 (dd, J = 9.3, 2.7 Hz, 1H), 7.53 (d, J = 2.1 Hz, 1H), 7.12 (s, 1H), 7.06 (s, 2H), 6.69 (d, J = 9.3 Hz, 1H), 6.22 (s, 1H), 4.07- 4.03 (m, 1H), 3.88-3.77 (m, 2H), 3.73-3.67 (m, 1H) , 2.64 (s, 3H), 2.56 (s, 3H), 2.51 (s, 3H), 2.39 (s, 3H), 2.27 (s, 3H), 1.64-1.50 (m, 13H), 1.46 (m, 3H), 1.12-0.75 (m, 20H). 13C NMR: (125 MHz, CD2CI2) delta ppm: 282.23 (d), 220.27, 219.73, 184.63 (d), 145.82, 139.23 (d), 139.08, 138.89, 137.46, 136.76, 136.69, 134.24, 134.00, 130.55, 130.36, 129.41 (d), 125.78, 117.59, 115.27, 52.14 (d), 51.63 (d), 34.52, 32.77, 32.64, 29.40, 28.91, 28.00 (m), 26.90 (d), 22.73, 21.34, 21.01, 19.41, 18.63, 18.53, 17.10, 14.21.

246047-72-3, As the paragraph descriping shows that 246047-72-3 is playing an increasingly important role.

Reference£º
Patent; APEIRON SYNTHESIS S.A.; SKOWERSKI, Krzysztof; BIENIEK, Micha?; WO2014/16422; (2014); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.246047-72-3,(1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium,as a common compound, the synthetic route is as follows.

1-(isopropylsulfanyl)-2-vinylbenzene (25.0 mg, 0.14 mmol), cuprous chloride (16.7 mg, 0.17 mmol) and (1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium (119 mg, 0.14 mmol) were dissolved in 6 mL dichloromethane in a 10 mL round-bottomed flask under dry nitrogen topped with a reflux condenser. The reaction mixture was refluxed for 4.5 h. The resulting mixture was evaporated to dryness. The crude product was purified by chromatography on silica gel using 7:3 n-hexane and acetone as eluent to give a teal solid (48.0 mg, 55%). Two additional byproducts were separated by chromatography, but only one was fully characterized by NMR analysis: the trans-catalyst isomer green solid (8.1 mg, 9%) and additional green solid (14.2 mg). Both spontaneously converted with time to product 1A according to NMR analysis. Crystals suitable for X-ray analysis were obtained by laying hexanes over a solution of 1A in dichloromethane for few days at -18 C. [0056] 1H NMR (500 MHz, CD2Cl2): delta 0.76 (d, J=6.5 Hz, 3H), 1.41 (d, J=7.4 Hz, 3H), 1.56 (s, 3H), 2.16 (s, 3H), 2.37 (s, 3H), 2.44 (s, 3H), 2.57 (s, 3H), 2.64 (s, 3H), 3.58 (m, 1H), 3.80 (m, 1H), 3.88 (m, 1H), 4.00 (m, 1H), 4.11 (m, 1H), 5.96 (bs, 1H), 6.79 (d, J=7.5 Hz, 1H), 6.88 (bs, 1H), 7.04 (bs, 1H), 7.12 (bs, 1H), 7.17 (t, J=6.4 Hz, 1H), 7.46 (m, 2H), 17.14 (s, 1H) ppm. 13C NMR (125 MHz, CDCl3): delta 17.7, 18.7, 19.7, 20.3, 20.9, 21.0, 21.3, 24.2, 39.0, 51.4, 51.6, 123.7, 128.6, 129.4, 129.6, 129.7, 129.8, 130.7, 131.7, 135.0, 135.4, 135.6, 137.3, 137.7, 138.5, 140.3, 140.4, 156.6, 213.6, 285.6 ppm. APCI-MS m/z (M-Cl)+: 607.1 (Calc. 607.15).

246047-72-3, As the paragraph descriping shows that 246047-72-3 is playing an increasingly important role.

Reference£º
Patent; LEMCOFF, N. Gabriel; BEN-ASULY, Amos; US2014/155511; (2014); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.246047-72-3,(1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium,as a common compound, the synthetic route is as follows.

In order to confirm by a series of compounds obtained by reaction of, reference the known method for the synthesis of beta, beta-di fluorophenyl ethylene. Furthermore, the known method of the reference (valeant literature 3, the following formula) synthesis of the (1,3-II Yl -4,5- dihydro imidazole -2-type methylene) (three ring hexyl phosphine ) methylene dichloride difluoromethane ruthenium. The following shows the results of these evaluations. These as spectrum standard, because of the above-mentioned of the internal liquid of the (mixture) is consistent with the NMR spectrum, so that the beta, beta-difluoro styrene and (1,3-II Yl -4,5- dihydro imidazole -2-type methylene) (three ring hexyl phosphine ) difluoro methylene b chlorize the generating., 246047-72-3

The synthetic route of 246047-72-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Asahi Glass Co., Ltd.; YUSUKE, TAKAHIRA; (43 pag.)CN105517982; (2016); A;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

(1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium, cas is 246047-72-3, it is a common heterocyclic compound, the ruthenium-catalysts compound, its synthesis route is as follows.,246047-72-3

Example 3 SYNTHESIS OF THE COMPLEX 3 ACCORDING TO THE INVENTION [0078] The commercially available complex G (200 mg, 0.24 mmol) was placed in a flask, to which methylene chloride was added (6 ml). This was followed by adding the compound of the formula: (63 mg, 0.47 mmol) and tricyclohexylphosphine (132 mg, 0.47 mmol). The resulting solution was stirred at a temperature of 40 C. for 5 hours. The reaction mixture was introduced at the top of a chromatographic column packed with silica gel (eluent: ethyl acetate/cyclohexane, 0 to 10 vol. %). After evaporating the solvents, the complex 3 was obtained as a green solid (140 mg, 72% yield). [0079] 1H NMR (500 MHz, CD2Cl2) delta ppm: 15.85 (s, 1H), 7.07 (s, 1H), 7.00-6.96 (m, 3H), 6.66 (d, J=8.4 Hz, 1H), 6.44 (dd, J=7.7, 1.4 Hz, 1H), 6.24 (s, 1H), 6.20 (t, J=7.2 Hz, 1H), 4.01-3.96 (m, 1H), 3.83-3.70 (m, 2H), 3.64-3.59 (m, 1H), 2.63 (s, 3H), 2.54 (s, 3H), 2.50 (s, 3H), 2.35 (s, 3H), 2.27 (s, 3H), 1.66-1.50 (m, 13H), 1.29 (s, 3H), 1.11-0.70 (m, 20H). 13C NMR: (125 MHz, CD2Cl2) delta ppm: 281.36, 222.21, 221.66, 180.31, 148.30, 139.54, 139.17, 138.78, 137.63, 137.32, 136.98, 134.69, 130.23, 130.05, 129.70, 129.00, 122.38, 116.17, 111.26, 32.52, 32.39, 29.45, 28.92, 28.23, 28.15, 28.12, 28.04, 27.34, 27.03, 21.33, 21.14, 19.40, 18.92, 18.66, 16.76. 31P NMR (124.5 MHz, CDCl3) delta ppm: 29.11.

As the rapid development of chemical substances, we look forward to future research findings about 246047-72-3

Reference£º
Patent; Skowerski, Krzysztof; Bieniek, Michal; US2015/158896; (2015); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.246047-72-3,(1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium,as a common compound, the synthetic route is as follows.

To a solution of 13b (40.0 mg, 0.065 mmol) in anhydrous CH2Cl2 (6.0 ml) was added2nd generation Grubbs catalyst (50.3 mg, 0.059 mmol) and CuCl (I) (13.0 mg, 0.13mmol) under nitrogen at 30 C and stirred for 3 h. The reaction mixture was concentrated in vacuo, and the residue was purified by column chromatography onsilica gel (hexane / AcOEt = 2 / 1) to give 3b (55.5 mg, 78%).green crystals; mp 160-165 C (dec.); 1H NMR (270 MHz, CDCl3) delta 2.01-2.04 (m, 2H),2.22-2.31 (m, 2H), 2.43 (d, J = 14.8 Hz, 18H), 2.77-2.87 (m, 4H), 4.10-4.21 (m, 6H),6.51 (s, 1H), 7.08 (s, 5H), 16.43 (s, 1H); 19F NMR (466 MHz, CDCl3) delta -80.5 (3F),-114.4 (2F), -121.5 (2F), -121.8 (4F), -122.5 (2F), -123.3 (2F), -126.0 (2F); 13C NMR(68 MHz, CDCl3) delta 19.2, 21.0, 22.5, 23.5, 51.7, 69.5, 77.5, 118.9, 124.1, 128.9, 129.5,133.2, 136.3, 138.7, 143.7, 148.5, 210.7, 291.4; IR (FT) 3905, 3857, 3816, 3743, 3700,3642, 3616, 3569, 3013, 2945, 2913, 2856, 2363, 2331, 1738, 1691, 1596, 1555, 1476,1455, 1413, 1245, 1203, 1140, 1108, 1035, 993, 915, 857, 814, 730 cm-1; HRMS (FAB)m/z [M+H]+ calcd for C41H40Cl2F17N2ORu 1072.1290, found 1072.1320.

246047-72-3, The synthetic route of 246047-72-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kobayashi, Yuki; Suzumura, Naoki; Tsuchiya, Yuki; Goto, Machiko; Sugiyama, Yuya; Shioiri, Takayuki; Matsugi, Masato; Synthesis; vol. 49; 8; (2017); p. 1796 – 1807;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

246047-72-3, (1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium is a ruthenium-catalysts compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A suspension of 100 mg (0.12 mmol) of [RuCl2(PCy3) (ImH2Mes)(phenylmethy- lene)], 12 mg (0.12 mmol) copper chloride and 100 mg (0.12 mmol) 2-phenyl-8-vinyl- quinoline-4-ol in 11 ml methylene chloride was stirred at 400C for 1 h. The reaction mixture was evaporated to dryness and the isolated crude product purified by silica gel chromatography (hexane / ethyl acetat 2:1) to yield 51 mg (61%) of the title compound as green crystals. MS: 711.1 (M+). 1H-NMR (300 MHz, CD2Cl2): 2.32 (s, 12H); 2.41 (s, 6H); 3.90 (s, 4H); 6.12-6.28 (br, IH); 6.80-6.92 (m, 2H); 6.98 (s, 4H); 7.04-7.14 (m, IH); 7.19 (t, J=7.1Hz, IH); 7.29 (d, J=6.9Hz, IH); 7.35 (d, J=7.5Hz, 2H); 7.49 (d, J=7.1Hz, IH); 7.80-8.00 (br, IH); 17.34 (s, IH)., 246047-72-3

As the paragraph descriping shows that 246047-72-3 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2008/644; (2008); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI