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Targeting nucleus DNA with a cyclometalated dipyridophenazineruthenium(II) complex

Recently, coordinatively saturated and substitutionally inert Ru(II) complexes have been investigated as anticancer agents. Herein a cyclometalated Ru(II) complex, [Ru(bpy)(phpy)(dppz)]+, was found to be rapidly taken up by cancer cells, and nearly 90% of the complex accumulated in the nuclei of cancer cells after a 2 h incubation. The anticancer activity of this complex was screened against a panel of cancer cell lines. Remarkably, it exhibited IC50 values that were an order of magnitude lower than those of cisplatin. This complex also displayed potencies superior to those of cisplatin against 3D tumor spheroids. Further studies revealed that the high DNA binding affinity of [Ru(bpy)(phpy)(dppz)]+ resulted in effective disruption of the binding of transcription factor NF-kappaB to DNA sequences, thereby inhibiting cellular transcription and leading to irreversible cancer cell apoptosis. Our work provides new insights into understanding the biological interactions and anticancer molecular mechanisms of DNA-specific Ru(II) polypyridyl complexes.

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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.37366-09-9, Name is Dichloro(benzene)ruthenium(II) dimer, molecular formula is C12H12Cl4Ru2. In a Article£¬once mentioned of 37366-09-9, Computed Properties of C12H12Cl4Ru2

Discovery and investigation of anticancer ruthenium-arene Schiff-base complexes via water-promoted combinatorial three-component assembly

The structural diversity of metal scaffolds makes them a viable alternative to traditional organic scaffolds for drug design. Combinatorial chemistry and multicomponent reactions, coupled with high-throughput screening, are useful techniques in drug discovery, but they are rarely used in metal-based drug design. We report the optimization and validation of a new combinatorial, metal-based, three-component assembly reaction for the synthesis of a library of 442 Ru-arene Schiff-base (RAS) complexes. These RAS complexes were synthesized in a one-pot, on-a-plate format using commercially available starting materials under aqueous conditions. The library was screened for their anticancer activity, and several cytotoxic lead compounds were identified. In particular, [(eta6-1,3,5-triisopropylbenzene)RuCl(4-methoxy-N-(2- quinolinylmethylene)aniline)]Cl (4) displayed low micromolar IC50 values in ovarian cancers (A2780, A2780cisR), breast cancer (MCF7), and colorectal cancer (HCT116, SW480). The absence of p53 activation or changes in IC50 value between p53+/+ and p53-/- cells suggests that 4 and possibly the other lead compounds may act independently of the p53 tumor suppressor gene frequently mutated in cancer.

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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

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Relative stability of half-sandwich eta6-benzene Ru(II) complexes of tridentate (2-pyridyl)alkylamine ligands of varying chelate ring-size: Nucleophilic addition of hydride ion onto the benzene ring

A full account of half-sandwich complexes of ruthenium(II) having three-legged “piano-stool” geometry supported by tridentate (2-pyridyl)alkylamine ligands is presented. Reaction of the dimer [{(eta6-C6H6)RuCl(mu-Cl)}2] with N-methyl-N,N-bis(2-pyridylmethyl)amine (MeL*) in CH3OH in the presence of NH4PF6 affords the complex [(eta6-C6H6)Ru(MeL*)][PF6]2 (1). A similar reaction with N-methyl-N,N-bis(2-pyridylethyl)amine (MeL**), however, affords a non-organometallic Ru(III)-dimeric complex [(MeL* *)2 Ru2III (mu -O) (mu -Cl) Cl2] [PF6] (5) (the composition of this complex has been established by physicochemical method). Nucleophilic addition reaction on 1 with NaBH4 leads to the isolation of a cyclohexadienyl complex [(eta5-C6H7)Ru(MeL*)][PF6] (3). The molecular structure of 1 ¡¤ 2CH3CN, 3, and previously reported cyclohexadienyl complex [(eta5-C6H7)Ru(MeL)][PF6] (4) [MeL = N-methyl-[(2-pyridyl)ethyl(2-pyridyl)-methyl]amine], obtained from the reaction between NaBH4 and previously reported “piano-stool” complex [(eta6-C6H6)Ru(MeL)][PF6]2 (2), has been confirmed by X-ray crystallography. Solution-state structure of new complexes 1 and 3 has been elucidated by their 1H NMR spectra in CD3CN. The behavior of complex 3 has been investigated with the aid of two-dimensional 1H NMR spectroscopy, as well. An attempt has been made to provide a rationale for the effect of supporting tridentate N-donor ligand [MeL, MeL*, and MeL**], varying in the chelate ring-size on (i) the relative stability of half-sandwich eta6-benzene Ru(II) complexes and (ii) the electrophilicity of Ru(II)-coordinated benzene ring on the nucleophilic addition reactions.

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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 37366-09-9, Name is Dichloro(benzene)ruthenium(II) dimer, molecular formula is C12H12Cl4Ru2. In a Article£¬once mentioned of 37366-09-9, SDS of cas: 37366-09-9

Mechanistic investigations on the hydrogenation of alkenes using ruthenium(II)-arene diphosphine complexes

The ruthenium(II) complexes [Ru(eta2-P-P)(eta6-p- cymene)Cl]Cl, P-P = diphenylphosphinomethane (dppm), diphenylphosphinoethane (dppe), or diphenylphosphinopropane (dppp), and the highly water-soluble analogues, [Ru(eta2-P-P)(eta6-arene)Cl]Na3, P-P = 1,2-bis(di-4-sulfonatophenylphosphino)benzene (dppbts), arene = p-cymene, benzene, or [2.2]paracyclophane, are efficient catalyst precursors for the hydrogenation of styrene in an aqueous biphase. By the use of high gas pressure NMR techniques and electrospay ionization mass spectrometry, the active species in the hydrogenation have been indirectly identified to be a dihydrogen complex, which also catalyzes H/D isotope exchange. Using the ruthenium(II) dppbts derivatives as precatalysts, evidence is provided for an arene exchange process that takes place during the catalytic hydrogenation of styrene. Together, these results lead to the proposition of a catalytic cycle for the hydrogenation of the C=C double bond of styrene using ruthenium(II)-arene diphosphine complexes.

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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

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Enantioselective transfer hydrogenation of pro-chiral ketones catalyzed by novel ruthenium and iridium complexes of well-designed phosphinite ligand

The interaction of [Ru(eta6-arene)(mu-Cl)Cl]2 and Ir(eta5-C5Me5)(mu-Cl)Cl]2 with a new Ionic Liquid-based phosphinite ligand, [(Ph2PO)-C6H9N2Ph]Cl, (2) gave [Ru((Ph2PO)-C6H9N2Ph)(eta6-p-cymene)Cl2]Cl (3), [Ru((Ph2PO)-C6H9N2Ph)(benzene)Cl2]Cl (4) and [Ir((Ph2PO)-C6H9N2Ph)(C5Me5)Cl2]Cl (5), complexes. All the compounds were characterized by a combination of multinuclear NMR and IR spectroscopy as well as elemental analysis. Furthermore, the Ru(II) and Ir(III) catalysts were applied to asymmetric transfer hydrogenation of acetophenone derivatives using 2-propanol as a hydrogen source. The results showed that the corresponding alcohols could be obtained with good activity (up to 55% ee and 99% conversion) under mild conditions. Notably, [Ir((Ph2PO)-C6H9N2Ph)(C5Me5)Cl2]Cl (5) is more active than the other analogous complexes in the transfer hydrogenation (up to 81% ee).

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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

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Heteroleptic arene Ru(ii) dipyrrinato complexes: DNA, protein binding and anti-cancer activity against the ACHN cancer cell line

Four organometallic complexes [(eta6-C6H6)RuCl(pmpzdpm)], 1; [(eta6-C6H6)RuCl(pypzdpm)], 2; [(eta6-C10H14)RuCl(pmpzdpm)], 3 and [(eta6-C10H14)RuCl(pypzdpm)], 4 containing 5-(2-pyrimidyl-piperazine)phenyldipyrromethene (pmpzdpm) and 5-(2-pyridylpiperazine)phenyldipyrromethene (pypzdpm) have been designed and synthesized. The complexes 1-4 have been fully characterized by elemental analyses and spectroscopic studies (ESI-MS, IR, 1H, 13C NMR, UV-vis). Their electrostatic/intercalative interaction with CT DNA has been investigated by UV-vis and competitive ethidium bromide displacement studies while their protein binding affinity toward bovine serum albumin (BSA) was realized by UV-vis, fluorescence, synchronous and three dimensional (3D) fluorescence studies. The interaction with DNA and protein has further been validated by in silico studies. Cellular uptake, in vitro cytotoxicity and flow cytometric analyses have been performed to determine the mode of cell death against the kidney cancer cell line ACHN. Cell cycle analysis suggested that the complexes cause cell cycle arrest in the subG1 phase and overall results indicated that the in vitro antitumor activity of 1-4 lies in the order of 3 > 4 > 1 > 2 (IC50, 7.0 1; 8.0 2; 2.0 3; 4.0 muM, 4).

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Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 37366-09-9, Name is Dichloro(benzene)ruthenium(II) dimer, molecular formula is C12H12Cl4Ru2. In a Article£¬once mentioned of 37366-09-9, SDS of cas: 37366-09-9

Cycloruthenated complexes from iminophosphoranes: Synthesis, structure, and reactivity with internal alkynes

Cycloruthenated complexes [(eta6-arene)Ru(C6H 4-2-PPh2=NR)Cl] (arene = benzene, p-cymene; R = Ph, H) containing orthometalated iminophosphoranes have been obtained by transmetalation reactions from Hg(C6H4-2-PPh 2=NR)2 derivatives to [(eta6-arene)Ru(mu- Cl)Cl]2. These complexes react cleanly with internal alkynes R 1C=CR2 (R1, R2 = Ph, Et, CO 2Me), KPF6, and CuBr2, yielding the 1,1,2-triphenyl-3,4-di(alkyl/aryl)-2,1lambda5-benzazaphosphinin-2- ium heterocycles [C6H4-PPh2-NPh-C(R 1)=C(R2)-3,4]+ as PF6 salts. In all studied cases only the monoinsertion products have been observed. In the case of the asymmetric alkyne MeC=CPh the insertion is regioselective, and the [C 6H4-PPh2-NPh-C(Me)=C(Ph)-3,4]PF6 salt is obtained.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.SDS of cas: 37366-09-9, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 37366-09-9, in my other articles.

Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.37366-09-9, Name is Dichloro(benzene)ruthenium(II) dimer, molecular formula is C12H12Cl4Ru2. In a Article£¬once mentioned of 37366-09-9, COA of Formula: C12H12Cl4Ru2

Synthesis and structural characterization of eta6-arene ruthenium complexes bearing pentadienyl and oxopentadienyl ligands

General methodology for the synthesis of cationic ruthenium(II) eta5-pentadienyl compounds stabilized by the (eta6- C6Me6)Ru fragment has been developed. Pentadienyl compounds [(eta6-C6Me6)Ru{eta5- CH2C-(R2)CHC(R4)CH(R5)}]BF 4 (R2 = R4 = R5 = H, 2-BF 4; R2, R4 = H, R5 = Me, 3; R 2, R4 = Me, R5 = H, 4) can be prepared in good yields from reactions of the labile dication [(eta6-C 6Me6)Ru(acetone)3](BF4)2 (1) with 1-trimethylsilyl-2,4-pentadiene, 1-trimethylsilyl-2,4-hexadiene, and 2,4-dimethyl-1-trimethylstannyl-2,4-pentadiene, respectively. Compound 3 is isolated in 90% yield as a mixture of the syn and anti isomers. In contrast, the reaction of pentadienyllithium with [(eta6-C6Me 6)RuCl2]2 provides a nonselective reaction, which affords a mixture of isomeric eta1- eta3-, and eta5-coordinated pentadienyl complexes, [(eta6-C 6Me6)Ru(eta5-CH2CHCHCHCH 2)]Cl (2-Cl), [(eta6-C6Me6) Ru(eta3-CH2CHCHCH=CH2)-Cl] (5), and [(eta6-C6Me6)Ru(eta1-CH 2CH=CHCH=CH2)Cl]2 (6); the reaction of 1,4-pentadiene and [(eta6-C6Me6)RuCl 2]2 in ethanolic carbonate similarly gives a mixture containing complex 5, [(eta6-C6Me6) Ru{eta3-C(Me)CHC(Me))Cl] (7), and [(eta6-C 6Me6)Ru(eta3-CH2CHCHCH 2Me)Cl] (8). Using a similar strategy for the synthesis of the corresponding oxopentadienyl derivatives is much more complicated, even when using an enol silane as the nucleophilic precursor, reflecting a greater competition among alternative bonding modes for the oxopentadienyl derivatives compared to the corresponding pentadienyl analogues. The reaction of lithium oxopentadienide and [(eta6-C6Me6)RuCl 2]2 in THF affords [(eta6-C 6Me6)Ru(eta3-exo-syn-CH2C(Me) CHC(Me)O)Cl] (11) in poor yield, although this complex readily affords [(eta-C6Me6)-Ru(eta5-CH2C(Me) CHC(Me)O)]BF4 (9) upon reaction with silver tetrafluoroborate. The analogous eta6-benzene complex, [(eta6-C 6H6)Ru(eta3-exo-syn-CH2C(Me) CHC(Me)O)Cl] (13), can be prepared, albeit in very low yield, in an analogous manner to that reported for complex 11, along with traces of an isomeric congener, 13-endo. The use of 1-trimethylsilyloxy-1,3-butadiene unexpectedly provided strongly contrasting results upon addition to dicationic complex 1, returning a mixture of eta5- and eta3-oxopentadienyl complexes [(eta6-C6Me6)Ru(eta5- CH2CHCHCHO)]BF4 (14) and [(eta6-C 6Me6)Ru(1-3,5-eta-exo-syn-CH2CHCHCHO)] 2-(BF4)2 (15). Addition of water to the dimeric product 15 affords the monomelic aquo adduct [(eta6-C 6-Me6)Ru(eta3-exo-syn-CH2CHCHCHO) (H2O)]BF4 (16), but this complex is unstable toward isolation, reverting back to dimer 15 upon precipitation. A more stable adduct, [(eta6-C6Me6)Ru(eta3-exo-syn- CH2-CHCHCHO)(MeCN)]BF4 (17), is isolated upon dissolution in acetonitrile, and addition of aqueous NaCl to 15 gives compound [(eta6-C6Me6)Ru(eta3-exo-syn- CH2CHCHCHO)Cl] (20). Compound 14 affords the decarbonylation product [(eta6-C6Me6)Ru(eta3-allyl)(CO)] BF4 (19) as a mixture of exo and endo allyl isomers. The solid-state structures for compounds 2-BF4, 4, 9, 11, 13, 15, and 19-exo, as determined by X-ray crystallography, are also reported.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 37366-09-9 is helpful to your research., COA of Formula: C12H12Cl4Ru2

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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 37366-09-9, Name is Dichloro(benzene)ruthenium(II) dimer, molecular formula is C12H12Cl4Ru2. In a Review£¬once mentioned of 37366-09-9, COA of Formula: C12H12Cl4Ru2

Synthesis, properties, and biosensor applications of cycloruthenated 2-phenylimidazoles

The cycloruthenation of 2-phenylimidazole (phim) by [Ru(eta6-C6H6)(mu-Cl)Cl]2 in acetonitrile in the presence of NaOH has been carried out. The unstable intermediate [Ru(phim)(MeCN)4]PF6 formed has been converted into the complexes [Ru(phim)(4,4?-Me2bpy) (MeCN)2]PF6 (2) and [Ru(phim)(LL)2]PF6 (3, LL=phen (a), bpy, 4,4?-Me2bpy), which were characterized by the mass-spectrometry, 1H-NMR spectroscopy, UV-vis spectrophotometry, and cyclic voltammetry. The RuII/III redox potentials of complexes 3 equal 130-250 mV (vs. Ag- AgCl) at pH 7 (0.01 M phosphate). Such potential range is favorable for fast exchange of electrons with the active sites of redox enzymes. In fact, the second-order rate constant for the oxidation of reduced glucose oxidase (GO) from Aspergillus niger by the electrochemically generated RuIII derivative of complex 3a equals (8.1 ¡Á 106M-1 s-1). The second-order rate constant for the oxidation of 3a by the Compound II of horseradish peroxidase is 9.3 ¡Á 107 M-1 s-1. Complexes 3 were used as mediators for the fabrication of enzyme electrodes by simple co-adsorbing with GO or horseradish peroxidase on graphite electrodes. These electrodes were tested in flow-injection systems and showed linear responses in the range of D-glucose and H2O2 concentrations 0.1-30 mM and 1-200 muM, respectively. The new mediators reported herein seem promising for the construction of amperometric biosensors based on GO, horseradish peroxidase, and similar enzymes.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.COA of Formula: C12H12Cl4Ru2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 37366-09-9, in my other articles.

Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 37366-09-9, Name is Dichloro(benzene)ruthenium(II) dimer, Formula: C12H12Cl4Ru2.

A carbon doped anatase TiO2 as a promising semiconducting layer in Ru-dyes based dye-sensitized solar cells

The synthesis and characterization of two simple Ruthenium(II) complexes of the type [Ru(X^N)2(4,4?-dicarboxybipyridine)]+ (with X[dbnd]C, X^N[dbnd]benzoquinolinate, 1; with X[dbnd]N, X^N[dbnd]2-pyridyl tetrazolate, 2) and the exploitation of a new carbon doped anatase TiO2 paste in dye-sensitized solar cells (DSSCs) photoanode are described. In particular, glucose (C6H12O6) is used as a new chemical eco-friendly C-dopant during the doping process of anatase TiO2 nanoparticles. The proper combination of Ru(II) sensitizers and C-doped titania can afford efficient DSSC photoanodes. All the relevant photovoltaic parameters have been determined.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Formula: C12H12Cl4Ru2. In my other articles, you can also check out more blogs about 37366-09-9

Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI