Category: ruthenium-catalysts

The ruthenium-catalysts compound, cas is 301224-40-8 name is (1,3-Dimesitylimidazolidin-2-ylidene)(2-isopropoxybenzylidene)ruthenium(VI) chloride, mainly used in chemical industry, its synthesis route is as follows.,301224-40-8

Hoveyda-Grubbs second generation catalyst (150 mg, 0.24 mmol) and potassium 2,4,6-trimethylbenzenethiolate 2c (59 mg, 0.31 mmol) were transferred to a 25 mL Schlenk flask, followed by addition of 5 mL of benzene and 1 mL of THF under argon. Then the mixture was stirred vigorously at 20 C. for 30 min. During this time the color of the mixture turned from light green to dark green. The reaction mixture was filtered, and the volume of the filtrate reduced to about 3 mL. Hexane (15 mL) was then added to the dark-green solution under stirring to precipitate the ruthenium complex 4c as a dark green powder (98.5 mg, 55.3%). Further purification was accomplished by dissolving the product in benzene and precipitating with hexane. Crystals for X-ray crystal structure determination were grown by slow diffusion of pentane to a concentrated solution of 4c in fluorobenzene, see FIG. 13 and Table 5. (0127) 1H NMR (400.13 MHz, CDCl3): delta=14.89 (s, 1H), 7.20 (m, 1H), 7.09 (s, 2H), 7.05 (s, 2H), 6.78-6.73 (m, 2H), 6.57 (br s, 1H), 6.14 (d, 1H), 5.99 (br s 1H), 4.13 (m, 4H), 3.95 (sep, 1H), 2.62 (s, 6H), 2.54 (s, 6H), 2.42 (s, 6H), 2.28 (br s, 3H), 2.03 (d, J=6.1 Hz, 3H), 0.92 (d, J=6.1 Hz, 3H), 0.81 (br s, 3H). 13C NMR (100.6 MHz, CD2Cl2): delta=269.24, 211.58, 151.83, 145.22, 139.26, 138.89, 138.82, 138.16, 133.95, 129.72, 129.39, 127.54, 127.30, 122.75, 122.40, 114.07, 75.20, 53.84, 52.25, 21.40, 21.20, 21.17, 20.79, 19.89. (0128) A corresponding ORTEP-style diagram of 4c is shown in FIG. 13. Selected geometrical parameters: Ru1-C16=1.842 , Ru1-S1=2.338 , Ru1-Cl1=2.375 , Ru1-O1=2.236 , Ru1-S1-C1=107.66, Cl1-Ru1-S1=159.61.

With the rapid development of chemical substances, we look forward to future research findings about 301224-40-8

Reference£º
Patent; Bergen Teknologioverforing AS; Jensen, Vidar R.; Occhipinti, Giovanni; Hansen, Frederick Rosberg; US8716488; (2014); B2;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The ruthenium-catalysts compound, cas is 301224-40-8 name is (1,3-Dimesitylimidazolidin-2-ylidene)(2-isopropoxybenzylidene)ruthenium(VI) chloride, mainly used in chemical industry, its synthesis route is as follows.,301224-40-8

General procedure: A mixture of fluorinated acid silver salt 6 (2.2eq.) and dichlororuthenium(IV) complex 5 (1.0eq.) was first dried under vacuum (13Pa) at room temperature for 1h. Dry dichloromethane (5mL) was added and the resulting mixture was stirred at room temperature for 3h in the dark. The solids were filtered off and washed with dry dichloromethane (2mL). Evaporation of the solvent afforded the product 7-9.

With the rapid development of chemical substances, we look forward to future research findings about 301224-40-8

Reference£º
Article; Babun?k, Mario; ?im?nek, Ond?ej; Ho?ek, Jan; Ryba?kova, Marketa; Cva?ka, Josef; B?ezinova, Anna; Kvi?ala, Jaroslav; Journal of Fluorine Chemistry; vol. 161; (2014); p. 66 – 75;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

10049-08-8, Ruthenium(III) chloride is a ruthenium-catalysts compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,10049-08-8

Example 13 Synthesis of (3S)-3-(1,3-benzodioxol-5-yl)-3-[({1-[2-oxo-3-(phenylmethyl)-1(2H)-pyridinyl]cyclohexyl}carbonyl)amino]propanoic Acid Step One: To a solution of 3-benzylpyridine (1.65 g, 9.77 mmol) in acetone (3.5 mL), 1-chloro-2,4-dinitrobenzene (2.00 g, 9.56 mmol) was added and the mixture was refluxed overnight. The mixture was cooled to room temperature, diluted with acetone and the solvent was decanted from the precipitate. The crude solid was washed with acetone (2 times) and diethyl ether (1 time), decanting each time to give 37(3.57 g, 100percent) as a gray solid. Step Two: To a solution of 1-amino-1-hydroxymethylcyclohexane (0.45 g, 3.5 mmol) in n-butanol (8.75 mL), solid N-(2,4-dintrophenyl)-3-benzylpyridinum chloride (37, 1.23 g, 3.3 mmol) was added. The resulting solution was heated to reflux for 2.5 days under a nitrogen atmosphere. The mixture was cooled, diluted with water and filtered. The filtrate was basified with concentrated NH4OH (2 mL) and extracted with ethyl acetate. The aqueous layer was concentrated to dryness to give 38(0.56 g) as a yellow oil which was used without further purification. Step Three: To a solution of crude 38(0.56 g, 3.5 mmol theoretical) in water (10 mL), a solution of potassium ferricyanide (3.3 g, 10 mmol) in water (15 mL) was added dropwise via an addition funnel over 30 minutes at 0¡ã C. A solution of KOH (0.76 g, 13.5 mmol) in water (5 mL) was then added over 30 minutes. Toluene (10 mL) was added and the solution was stirred for one hour at 0¡ã C. The layers were separated, and the aqueous layer was extracted again with toluene. The combined extracts were dried over Na2SO4 and filtered and the filtrate was concentrated under reduced pressure. The residue was chromatographed on silica gel, eluding with 7:13 hexanes:ethyl acetate to give 39(20 mg, 1.9percent, two steps.) Step Four: To a suspension of 39(20 mg, 0.068 mmol) in aqueous KOH (1M, 0.70 mL) potassium persulfate (0.073 g, 0.270 mmol) and ruthenium (III) chloride (1 mg, catalytic) and THF (0.25 mL) were added. The mixture was stirred for 1 hour and extracted with dichloromethane. The aqueous layer was acidified and extracted with ethyl acetate (3 times). The ethyl acetate extracts were combined, dried over MgSO4 and filtered. The filtrate was concentrated under reduced pressure to give 40(0.0148 g, 70percent) as a tan solid. (3S)-3-(1,3-Benzodioxol-5-yl)-3-[({1-[2-oxo-3-(phenylmethyl)-1(2H)-pyridinyl]cyclohexyl}carbonyl)amino]propanoic acid was prepared from 40according to the procedures described in Example 1. 1H NMR (400 MHz, CD3SO2CD3): delta 1.40 (m, 4H), 1.68 (m, 2H), 2.04 (m, 2H), 2.60 (d, J=7.0 Hz, 2H), 3.67 (d, J=15.2 Hz, 1H), 3.72 (d, J=15.2 Hz, 1H), 5.12 (m, 1H), 5.95 (m, 2H), 6.19 (t, J=7.0 Hz, 1H), 6.74 (dd, J=7.8, 1.4 Hz, 1H), 6.76 (d, J=7.8 Hz, 1H), 6.90 (d, J=1.4 Hz, 1H), 7.10 (d, J=5.8 Hz, 1H), 7.20 (m, 5H), 7.57 (d, J=8.4Hz, 1H), 7.66 (dd, J=7.7, 1.8 Hz, 1H).

As the paragraph descriping shows that 10049-08-8 is playing an increasingly important role.

Reference£º
Patent; Biediger, Ronald J.; Dupre, Brian; Hamaker, Linda K.; Holland, George W.; Kassir, Jamal M.; Li, Wen; Market, Robert V.; Nguyen, Noel; Scott, Ian L.; Wu, Chengde; Decker, E. Radford; US2003/199692; (2003); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.301224-40-8,(1,3-Dimesitylimidazolidin-2-ylidene)(2-isopropoxybenzylidene)ruthenium(VI) chloride,as a common compound, the synthetic route is as follows.,301224-40-8

General procedure: A mixture of fluorinated acid silver salt 6 (2.2eq.) and dichlororuthenium(IV) complex 5 (1.0eq.) was first dried under vacuum (13Pa) at room temperature for 1h. Dry dichloromethane (5mL) was added and the resulting mixture was stirred at room temperature for 3h in the dark. The solids were filtered off and washed with dry dichloromethane (2mL). Evaporation of the solvent afforded the product 7-9.

As the paragraph descriping shows that 301224-40-8 is playing an increasingly important role.

Reference£º
Article; Babun?k, Mario; ?im?nek, Ond?ej; Ho?ek, Jan; Ryba?kova, Marketa; Cva?ka, Josef; B?ezinova, Anna; Kvi?ala, Jaroslav; Journal of Fluorine Chemistry; vol. 161; (2014); p. 66 – 75;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

20759-14-2, Ruthenium(III) chloride hydrate is a ruthenium-catalysts compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,20759-14-2

(4) Preparation of trans-3′-oxospiro[cyclohexane-1,1′(3’H)-isobenzofuran]-4-carboxylic acid A mixture of 4-hydroxymethylspiro[cyclohexane-1,1′(3’H)-isobenzofuran]-3’one (190 mg), chloroform (2.0 mL), acetonitrile (2.0 mL) and sodium phosphate buffer (pH6.5, 2.0 mL) was cooled to 0 C., to which sodium periodate (612 mg) and ruthenium(III) chloride n-hydrate (10 mg) were added and the mixture was stirred for 30 minutes. The reaction mixture was stirred together with 1N hydrochloric acid (2.0 mL) for 30 minutes and partitioned between water (50 mL) and ethyl acetate (50 mL). The organic layer was washed with saturated saline solution, dried over anhydrous Na2SO4 and then concentrated. The residue was purified by column chromatography on silica gel (chloroform/methanol=100/1) to give the subject compound (98.6 mg).

The synthetic route of 20759-14-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Banyu Pharmaceutical Co., Ltd.; US6803372; (2004); B2;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.301224-40-8,(1,3-Dimesitylimidazolidin-2-ylidene)(2-isopropoxybenzylidene)ruthenium(VI) chloride,as a common compound, the synthetic route is as follows.,301224-40-8

Potassium 2,4,6-triphenylthiophenolate 2d (53 mg, 0.14 mmol) was transferred to a 25 mL Schlenk flask, followed by addition of 5 mL of THF under argon, and the mixture was stirred vigorously and heated at 55 C. Hoveyda-Grubbs second generation catalyst (82 mg, 0.13 mmol) dissolved in toluene (1 mL) was then added, and the mixture stirred at 55 C. for 2.5 h. The solvents were then removed in vacuo, and the product was redissolved in 6 mL Et2O. Following filtration, 3 mL of hexane was added, and the mixture cooled to -40 C., causing precipitation of impurities. After allowing solids to settle, the solution was filtrated, and the solvents removed in vacuo to yield the crude 4d complex as a green powder (50.7 mg, 42%). 1H NMR (400.13 MHz, C6D6): delta=14.50 (s, 1H), 7.80 (d, J=6.4 Hz, 2H), 7.47 (t, J=6.7 Hz, 2H), 7.42-7.34 (m, 2H), 7.31-7.21 (m, 3H), 7.11 (t, J=7.2 Hz, 3H), 7.08-7.00 (m, 3H), 6.99-6.90 (m, 3H), 6.87 (s, 2H), 6.79-6.60 (m, 4H), 6.15 (d, J=8.2 Hz, 2H), 4.15 (sept, J=6.1 Hz, 1H), 3.38-3.20 (m, 4H), 2.47 (s, 6H), 2.38 (s, 6H), 2.29 (s, 6H), 1.15 (d, J=6.1 Hz, 3H), 0.59 (d, J=6.1 Hz, 3H). (0132) 13C NMR (100.6 MHz, CD2Cl2): delta=276.55, 210.42, 153.68, 146.72, 138.75, 138.16, 131.23, 129.58, 129.12, 128.97, 128.75, 128.31, 127.87, 127.77, 127.50, 127.23, 127.01, 125.83, 122.65, 121.72, 113.38, 76, 15, 53, 87, 51, 98, 21.54, 21.25, 20.83, 19.92, 19.04. MS (DART), m/z: 928.27512 (M+H)+; calc. for C55H56OClN2SRu: 928.27671.

As the paragraph descriping shows that 301224-40-8 is playing an increasingly important role.

Reference£º
Patent; Bergen Teknologioverforing AS; Jensen, Vidar R.; Occhipinti, Giovanni; Hansen, Frederick Rosberg; US8716488; (2014); B2;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.918870-76-5,Dichloro[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene][[5-[(dimethylamino)sulfonyl]-2-(1-methylethoxy-O)phenyl]methylene-C]ruthenium(II),as a common compound, the synthetic route is as follows.,918870-76-5

Example 103 Synthesis of Ru complex 6h The Ru complex (Zhan catalyst 2b, l.Ommol) and a new ligand 5h (1.5mmol) were dissolved in 20 mL of anhydrous DCM and reacted directly to form the desired Ru complex 6h in the preaence of CuCl (3.0mmol) in a 100 mL of three-neck flask filled with inert gas (Ar). The reaction mixture was stirred for 0.5 hr at room temperature. After complete, the reaction solution was filtered and purified by flask column. 378mg of yellow-green solid product 6h was obtained, yield: 52%. Ru complex 6h is confirmed by 1HNMR (400 MHz, CDC13): delta 16.52 (s, 1H, Ru=CH), 8.43 (s, 1H, N=CH), 8.10 (s, 1H), 7.46-7.22 (m, 2H), 7.73-6.96 (m, 8H), 4.19 (s, 4H, NCH2CH2N), 3.95 (s, 3H), 3.87 (s, 3H), 2.49 (s, 12H), 2.48 (s, 6H).

As the paragraph descriping shows that 918870-76-5 is playing an increasingly important role.

Reference£º
Patent; ZANNAN SCITECH CO., LTD.; ZHAN, James Zheng-Yun; WO2011/79439; (2011); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Dichloro[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene][[5-[(dimethylamino)sulfonyl]-2-(1-methylethoxy-O)phenyl]methylene-C]ruthenium(II), cas is 918870-76-5, it is a common heterocyclic compound, the ruthenium-catalysts compound, its synthesis route is as follows.,918870-76-5

Example 103 Synthesis of Ru complex 6h The Ru complex (Zhan catalyst 2b, l.Ommol) and a new ligand 5h (1.5mmol) were dissolved in 20 mL of anhydrous DCM and reacted directly to form the desired Ru complex 6h in the preaence of CuCl (3.0mmol) in a 100 mL of three-neck flask filled with inert gas (Ar). The reaction mixture was stirred for 0.5 hr at room temperature. After complete, the reaction solution was filtered and purified by flask column. 378mg of yellow-green solid product 6h was obtained, yield: 52%. Ru complex 6h is confirmed by 1HNMR (400 MHz, CDC13): delta 16.52 (s, 1H, Ru=CH), 8.43 (s, 1H, N=CH), 8.10 (s, 1H), 7.46-7.22 (m, 2H), 7.73-6.96 (m, 8H), 4.19 (s, 4H, NCH2CH2N), 3.95 (s, 3H), 3.87 (s, 3H), 2.49 (s, 12H), 2.48 (s, 6H).

With the synthetic route has been constantly updated, we look forward to future research findings about Dichloro[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene][[5-[(dimethylamino)sulfonyl]-2-(1-methylethoxy-O)phenyl]methylene-C]ruthenium(II),belong ruthenium-catalysts compound

Reference£º
Patent; ZANNAN SCITECH CO., LTD.; ZHAN, James Zheng-Yun; WO2011/79439; (2011); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

As a common heterocyclic compound, it belong ruthenium-catalysts compound,Dichloro(cycloocta-1,5-diene)ruthenium(II),50982-12-2,Molecular formula: C8H12Cl2Ru,mainly used in chemical industry, its synthesis route is as follows.,50982-12-2

Complex C-l was also prepared using [RuCl2(COD)]n as a precursor. Thus, a mixture of [RuCl2(COD)]n (309 mg, 1.103 mmol), PPh3 (289 mg, 1.103 mmol) and ligand Id (248 mg, 1.103 mmol) was stirred in toluene (10 ml) at 115C for 24 h in a KONTES pressure tube. After cooling, the resulting brick colored precipitate was filtered on a filter frit, washed with diethyl ether (3 x 10 ml) and vacuum dried to afford 494 mg of a light pink crude material (Found C, 53.43; H, 5.26; N, 4.08%). Recrystallization from hot THF, filtering and layering with diethyl ether, afforded burgundy crystals (261 mg, 32% yield as a THF solvate). Based on NMR analysis, these crystals represent a THF solvate of complex C-l. The crystals were found to lose solvent based on elemental analysis. Elem. Anal: Calc’d for C3oH35Cl2N2PRuS (658.63): C, 54.71; H, 5.36; N, 4.25%; Found C, 54.37; H, 5.66; N, 3.87%.

With the synthetic route has been constantly updated, we look forward to future research findings about Dichloro(cycloocta-1,5-diene)ruthenium(II),belong ruthenium-catalysts compound

Reference£º
Patent; LOS ALAMOS NATIONAL SECURITY, LLC; DUB, Pavel, A.; GORDON, John, Cameron; WO2015/191505; (2015); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

As a common heterocyclic compound, it belong ruthenium-catalysts compound,Dichloro(cycloocta-1,5-diene)ruthenium(II),50982-12-2,Molecular formula: C8H12Cl2Ru,mainly used in chemical industry, its synthesis route is as follows.,50982-12-2

[HNEt3][7,8-nido-C2B9H12] (0.400 g, 1.71 mmol) was suspended in degassed ether (35 mL). n-BuLi (1.40 mL, 3.50 mmol) was added, giving a pale yellow suspension which was stirred under N2 for 1 h, then heated at reflux for 90 min. The resulting solution was filtered, and the ether removed in vacuo to give a yellow oily solid which was subsequently dissolved in degassed THF (35 mL). [RuCl2(COD)]x (0.560 g, 2.00 mmol) and a large excess of naphthalene were added to the THF solution. The resulting brown mixture was heated at reflux for 90 min, then allowed to cool to room temperature. The brown mixture was filtered through a short silica column eluting with DCM to afford a brown solution, removal of solvent from which yielded a brown solid. This was further purified by column chromatography (1:2 DCM:40-60 petroleum ether) giving a yellow band, followed by preparative TLC (2:1 DCM:40-60 petroleum ether). C12H19B9Ru requires: C 39.85, H 5.30. Found: C 39.87, H 5.53%.

With the synthetic route has been constantly updated, we look forward to future research findings about Dichloro(cycloocta-1,5-diene)ruthenium(II),belong ruthenium-catalysts compound

Reference£º
Article; Scott, Greig; Ellis, David; Rosair, Georgina M.; Welch, Alan J.; Journal of Organometallic Chemistry; vol. 721-722; (2012); p. 78 – 84;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI