Category: ruthenium-catalysts

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50982-12-2,Dichloro(cycloocta-1,5-diene)ruthenium(II),as a common compound, the synthetic route is as follows.

1,2-closo-C2B10H12 (0.400 g, 2.77 mmol) was dissolved in degassed THF (35 mL). Na metal (0.300 g, 13.04 mmol) and naphthalene (ca. 15 mg) were added and the solution stirred overnight. The resulting dark green solution was transferred via a gas-tight syringe into a second Schlenk tube containing [RuCl2(COD)]x (0.650 g, 2.32 mmol) and a large excess of naphthalene. The resulting brown mixture was heated at reflux for 90 min then allowed to cool to room temperature. The brown mixture was filtered through a short silica column eluting with DCM to afford a brown solution, removal of solvent from which yielded a brown solid. This was further purified by column chromatography (1:2 DCM:40-60 petroleum ether), giving a yellow band, followed by preparative TLC (4:3 DCM:40-60 petroleum ether, Rf 0.55) yielding, as major product C12H20B10Ru requires C 38.59, H 5.40. Found: C 38.01, H 5.67%.

As the paragraph descriping shows that 50982-12-2 is playing an increasingly important role.

Reference£º
Article; Scott, Greig; Ellis, David; Rosair, Georgina M.; Welch, Alan J.; Journal of Organometallic Chemistry; vol. 721-722; (2012); p. 78 – 84;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50982-12-2,Dichloro(cycloocta-1,5-diene)ruthenium(II),as a common compound, the synthetic route is as follows.

A nitrogen-flushed three-neck flask was charged with 65.36 g of ruthenium trichloride trihydrate, 500 mL of ethanol and 250 mL of 1,5-cyclooctadiene, and the flask contents were refluxed under heating at 85 C. for 5 hours. Following the completion of refluxing, the solution was cooled to room temperature, after which filtration was carried out. The resulting solid was washed with 500 mL of diethyl ether and dried in vacuo, yielding 70.02 g of (eta-1,5-cyclooctadiene)ruthenium(II) dichloride as a brown solid. Next, 2.81 g of this (eta-1,5-cyclooctadiene)ruthenium(II) dichloride, 6.38 g of sodium carbonate, 2.9 mL of methyl 3-oxo-4,4,4-trifluorobutanoate and 10 mL of ethanol were placed in a nitrogen-flushed three-neck flask and refluxed under heating at 85 C. for 2 hours. Following the completion of refluxing, the solution was cooled to room temperature, then alumina column chromatography (developing solvent: acetone) was carried out. The resulting solution was concentrated and dried under reduced pressure, and 3.61 g of bis(methyl-3-oxo-4,4,4-trifluorobutanato)(eta-1,5-cyclooctadiene)ruthenium(II) was obtained as a black reddish-brown liquid. The yield was 66 wt %.

The synthetic route of 50982-12-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JSR Corporation; US2012/282414; (2012); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

301224-40-8, (1,3-Dimesitylimidazolidin-2-ylidene)(2-isopropoxybenzylidene)ruthenium(VI) chloride is a ruthenium-catalysts compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

HII 65 HII (200mg) and P(0’Pr)3 (5eq) were stirred in for 72h. The crude 65 was recrystallised from DCM/pentane. (400MHz, 298K): 16.05 (d, 1 H, J = 35.3 Hz, C=CH), 10.24 (d, 1 H, J = 9.7 Hz, Ph-H), 6.87-6.83 (m, 2H, Ph-H), 6.78 (s, 1 H, Ph-H), 6.61 (s, 1 H, Ph-H), 6.19-6.16 (m, 2H, Ph- H), 4.67 (brs, 2H, PO-CH-CH3), 4.09-4.06 (m, 1 H, Ph-0-CH-CH3), 4.04 (brs, 1 H, PO- CH-CH3), 3.43-3.40 (m, 1 H), 3.16-3.02 (m, 3H), 2.89 (s, 3H, Mes-CH3), 2.58 (s, 3H, CH3), 2.46 (s, 3H, CH3), 2.42 (s, 3H, CH3), 2.18 (s, 3H, CH3), 1.92 (s, 3H, CH3), 1.48- 0.80 (m, 24H, PO-CH-CH3).31P{1H} (121.49MHz, 298K): 128.7 (s)

301224-40-8 (1,3-Dimesitylimidazolidin-2-ylidene)(2-isopropoxybenzylidene)ruthenium(VI) chloride 11763533, aruthenium-catalysts compound, is more and more widely used in various.

Reference£º
Patent; UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS; CAZIN, Catherine; WO2011/117571; (2011); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50982-12-2,Dichloro(cycloocta-1,5-diene)ruthenium(II),as a common compound, the synthetic route is as follows.

0.25 g of metal sodium was mixed with well dried tetrahydrofuran in a 100 ml flask whose inside had been substituted by nitrogen and cooled to -78 C. A solution of 1.3 g of trimethylsilyl cyclopentadiene dissolved in 30 ml of tetrahydrofuran was added dropwise to the above solution in a stream of nitrogen over 1 hour and heated to room temperature under agitation over 3 hours to obtain a tetrahydrofuran solution of trimethylsilyl cyclopentadienyl sodium. Separately, 18 ml of a tetrahydrofuran solution (2.0 mol/l) of cyclopentadienyl sodium was prepared. Further separately, 5 g of dichloro(1,5-cyclooctadienyl)ruthenium was dissolved in 200 ml of well dried tetrahydrofuran in a 500 ml flask whose inside had been substituted by nitrogen. This solution was cooled to -78 C., and the above tetrahydrofuran solution of trimethylsilyl cyclopentadienyl sodium and the above tetrahydrofuran solution of cyclopentadienyl sodium were added dropwise to the solution at the same time in a stream of nitrogen over 1 hour. The resulting solution was stirred at -78 C. for 3 hours and heated to room temperature under agitation over 12 hours. After the resulting solution was let pass through a neutral alumina column in an argon gas atmosphere to be purified and concentrated, it was separated and purified by a neutral alumina column again to obtain 0.23 g of trimethylsilyl cyclopentadienyl(cyclopentadienyl)ruthenium (yield rate of 4.3%).

The synthetic route of 50982-12-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JSR Corporation; US2006/240190; (2006); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10049-08-8,Ruthenium(III) chloride,as a common compound, the synthetic route is as follows.

Step 1 To a solution of 2-(4,4-dimethyl-chroman-7-yl)-heptan-1-ol (0.27 g, 0.98 mmole, from Example 1, step 6) in a mixture of 2 mL of carbon tetrachloride, 2 mL acetonitrile and 3 mL water, containing 3-5 mg of ruthenium chloride, was added 0.85 g of sodium periodate. The mixture was stirred at room temperature for 2 hours, diluted with 10 mL of water, and pH was adjusted to 2 with 10percent hydrochloric acid. The mixture was extracted with three 10 mL portions of dichloromethane. The organic phase was dried over MgSO4, filtered and concentrated in vacuo to give a dark oil. The product was purified by flash chromatography (SiO2, gradient from 0 to 20percent ethyl acetate in hexanes) to yield 0.16 g of 2-(4,4-dimethyl-chroman-7-yl)-heptanoic acid as a pale yellow oil.

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Reference£º
Patent; Syntex (U.S.A.) LLC; US2003/158178; (2003); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10049-08-8,Ruthenium(III) chloride,as a common compound, the synthetic route is as follows.

[(1S,3R)-1-(Methoxycarbonylamino-methyl)-3-methyl-cyclopentyl]-acetic acid ((1S,3R)-1-Benzyl-3-methyl-cyclopentylmethyl)-carbamic acid methyl ester (2.6 g, 9.9 mmol) and sodium periodate (29.8 g, 140 mmol) were stirred together in carbon tetrachloride (30 mL), acetonitrile (30 mL), and water for 6 hours. The mixture was cooled to 0¡ã C., and ruthenium(III) chloride (0.04 g, 0.2 mmol) was added to the reaction mixture. The reaction was allowed to warm to room temperature and stirred for 20 hours. Diethyl ether (50 mL) was added, and the mixture was then extracted with saturated aqueous sodium hydrogen carbonate (200 mL). The aqueous layer was acidified to pH 1 with 4N hydrochloric acid and re-extracted with ethyl acetate (200 mL), dried (MgSO4), and the solvent was evaporated under reduced pressure. The residue was purified by chromatography (silica gel, eluding with a gradient of heptane to 1:1 heptane:ethyl acetate) to give 0.32 g (14percent) of [(1S,3R)-1-(methoxycarbonylamino-methyl)-3-methyl-cyclopentyl]-acetic acid; Rf (heptane-ethyl acetate, 8:2) 0.30; IR thin film (cm-1) 3338 (NH), 1712 (C=O); 1H-NMR (400 MHz; CDCl3): delta 9.29 (1H, s, COOH), 5.17 (1H, bs, NH), 3.71 (3H, s, OMe), 3.30 (1H, dd, J 14.4, 7.1, CHAHBNH2), 3.17 (1H, dd, J 14.4, 6.6, CHAHBNH2), 2.37 (2H, s, CH2COOH), 2.20-1.00 (7H, m), 1.01 (3H, d, J 6.4, CHMe); MS (ES+) m/z 230 (M+H, 63percent), 481 (M+Na,100).

The synthetic route of 10049-08-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bryans, Justin Stephen; Blakemore, David Clive; Williams, Sophie Caroline; US2003/69438; (2003); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.301224-40-8,(1,3-Dimesitylimidazolidin-2-ylidene)(2-isopropoxybenzylidene)ruthenium(VI) chloride,as a common compound, the synthetic route is as follows.

General procedure: In a glove box, a flask was charged with Ru complex 4 or 5 and Ag salt 3. Anhydrous degassed CH2Cl2 was then added and the resulting mixture was stirred at room temperature for 3h in the dark. The solids were filtered off through a Celite layer and washed with anhydrous (2mL). The solution was diluted with anhydrous hexane (10mL) and remaining precipitated Ag salt was again filtered off. Evaporation of the solvents on a rotary vacuum evaporator (40C, 1h, 25kPa) and finally at oil pump vacuum (25C, 1h, 1kPa) gave the products 1 or 2.

As the paragraph descriping shows that 301224-40-8 is playing an increasingly important role.

Reference£º
Article; Lipovska, Pavlina; Rathouska, Lucie; ?im?nek, Ond?ej; Ho?ek, Jan; Kola?ikova, Viola; Ryba?kova, Marketa; Cva?ka, Josef; Svoboda, Martin; Kvi?ala, Jaroslav; Journal of Fluorine Chemistry; vol. 191; (2016); p. 14 – 22;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

50982-12-2, Dichloro(cycloocta-1,5-diene)ruthenium(II) is a ruthenium-catalysts compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Next, 31.56 g of this (eta-1,5-cyclooctadiene)ruthenium(II) dichloride, 34.97 g of sodium carbonate, 28 mL of 2,4-pentanedione and 100 mL of N,N-dimethylformamide were placed in a nitrogen-flushed three-neck flask and stirred at 140 C. for 1 hour. Following reaction completion, the solution was cooled to room temperature, then alumina column chromatography (developing solvent: diethyl ether) was carried out. The resulting solution was concentrated, after which 120 mL of water was added and the solution was left at rest for 3 hours. The crystals that precipitated out were collected by filtration, and after being washed with water, were dried in vacuo. 46.53 g of bis(2,4-pentanedionato)(eta-1,5-cyclooctadiene)ruthenium(II) was obtained as an orangey-yellow solid. The yield was 94 wt %.

50982-12-2 Dichloro(cycloocta-1,5-diene)ruthenium(II) 11000435, aruthenium-catalysts compound, is more and more widely used in various.

Reference£º
Patent; JSR Corporation; US2012/282414; (2012); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

301224-40-8, (1,3-Dimesitylimidazolidin-2-ylidene)(2-isopropoxybenzylidene)ruthenium(VI) chloride is a ruthenium-catalysts compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a Schlenk flask the corresponding starting material (1 equiv)was dissolved in degassed CH2Cl2. 5,7-Dihalide-8-hydroxyquinoline(20 equiv) and Cs2CO3 (20 equiv) were added. Thereaction mixture was stirred under an atmosphere of argon for12 h at 25 C. Insoluble components were removed by filtrationover celite. Column chromatography (silica gel) using cyclohexane/ethylacetate = 10/1 (v/v) yielded the correspondingcomplexes. The synthesis of the following Ru-based complexesbelongs to a patent application [63].

As the paragraph descriping shows that 301224-40-8 is playing an increasingly important role.

Reference£º
Article; Wappel, Julia; Fischer, Roland C.; Cavallo, Luigi; Slugovc, Christian; Poater, Albert; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 154 – 165;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.301224-40-8,(1,3-Dimesitylimidazolidin-2-ylidene)(2-isopropoxybenzylidene)ruthenium(VI) chloride,as a common compound, the synthetic route is as follows.

Hoveyda-Grubbs second generation catalyst H2 (104 mg, 0.16 mmol) and potassium 2,6-dimethylbenzenethiolate (34 mg, 0.19 mmol) 2b were transferred to a 25 mL Schlenk flask, followed by addition of 4 mL of toluene and 1 mL THF under argon. Then the mixture was stirred vigorously at 20 C. for 30 min. During this time the color of the mixture turned from light green to a slightly darker green. The reaction mixture was filtered, and the volume of the filtrate reduced to about 3 mL. Hexane (15 mL) was added to the filtrate to precipitate the product 4b as red/orange-brown micro-crystals (86.3 mg, 71%). (0121) Crystals for X-ray diffraction analysis (see FIG. 12 and Table 4) were prepared by dissolving a sample in a minimal amount of toluene, upon which a layer of hexane was added. Red-brown crystals were formed over a period of 3 days at room temperature. (0122) 1H NMR (400.13 MHz, CDCl3): delta=14.90 (s, 1H), 7.22 (m, 1H), 7.10 (s, 2H), 7.06 (s, 2H), 6.80-6.73 (m, 2H), 6.66 (t, J=7.2 Hz, 1H), 6.16 (d, J=8.0 Hz, 1H), 4.15 (m, 4H), 3.83 (sep, J=6.16 Hz, 1H), 2.62 (s, 6H), 2.54 (s, 6H), 2.42 (s, 6H), 2.32 (br s, 3H), 1.8 (d, J=5.6 Hz, 3H), 0.89 (d, J=6.4 Hz, 3H), 0.80 (br s, 3H). 13C NMR (100.6 MHz, CDCl3): delta=271.29, 211.87, 151.57, 145.12, 142.30 (br), 141.67, 139.25, 138.90, 138.75, 137.40 (br), 129.74, 129.43, 127.32, 126.61, 124.43, 123.12, 122.34, 114.19, 74.99, 52.15, 21.55, 21.45, 21.43, 20.07 (br). (0123) A corresponding ORTEP-style diagram of 4b is shown in FIG. 12. Selected geometrical parameters: Ru1-C9=1.846 , Ru1-S1=2.285 , Ru1-Cl1=2.364 , Ru1-O1=2.298 , Ru1-S1-C1=113.67, Cl1-Ru1-S1=150.75.

The synthetic route of 301224-40-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bergen Teknologioverforing AS; Jensen, Vidar R.; Occhipinti, Giovanni; Hansen, Frederick Rosberg; US8716488; (2014); B2;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI